We just had some similar discussion in an email thread with @akosmaroy , @Gnip , @mamaya and @alecrimi
Would be ace to combine the discussion.
"A read you on finding homologies in DNA for the message one wants to ‘encode’ - as this would not need encoding, just the ‘pointer’ for where to find it in existing DNA and the decoding algo for the message. I thought of this back in the '90s too. Since my assessment was that the available DNA data is just not ‘big enough’ and doesn’t have the variance need to ‘already contain all possible messages’ we’d want to ‘encode’.
Personally I’m more interesting in the approach Alessandro brought up, by actually ‘writing’ DNA into some creature. One way to do it would be to reproduce the results from this article: CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria https://www.nature.com/articles/nature23017/ , maybe this is a better link: CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria
They were using a CRISPR technique on a specific strain of e.coli. I’ve done DNA transformations in the past but not CRISPR. Does anyone have experience with CRISPR at the Bitwascherei?"
We don’t yet have so much experience here in Bitwäscherei Open Science Lab… but we have already done the legal admin to be able to work on such experiments, incl the BSL1 registration with the etra tick on the CRISPR experiments.